Förutsatt att du har MySQLdb (mysql-python) installerad:
sql = "INSERT INTO mytable (a,b,c) VALUES (%(qwe)s, %(asd)s, %(zxc)s);"
data = {'qwe':1, 'asd':2, 'zxc':None}
conn = MySQLdb.connect(**params)
cursor = conn.cursor()
cursor.execute(sql, data)
cursor.close()
conn.close()